It is a new option in prenatal screening for Down syndrome (trisomy 21), Edwards syndrome (trisomy 18 ), Patau’s Syndrome (trisomy 13) and also common chromosomal conditions associated with X and Y chromosome . You and your guest are required to wear a mask or face covering, in line with UK government guidance. A study performed by The American College of Medical Genetics in 2016 correctly identified the gender in 786 of 787 cases. The Harmony blood test is not intended nor validated for diagnosis or detection of mosaicism, partial trisomy, or translocations. The websites of most private providers state that NIPT is ‘99% accurate’ or has ‘99% sensitivity’. All our sonographers are fully trained and qualified to perform ultrasound scans and many of them also work in the NHS locally. Our research suggests that costs for NIPT range from £350 to £550. It is important to realise that in this case the CVS or amniocentesis will most often confirm that the baby has Down's syndrome. We’re also registered with the independent regulator the Care Quality Commission to ensure the highest standards possible. A high chance of the foetus being affected by Down syndrome. The Laboratory offers foetal sex testing and the sex chromosome aneuploidy panel testing as additional complimentary investigations. More information on the Warwick Evidence Systematic Review can be found. When you book online, depending on your chosen location you may be contacted to arrange the most convenient way for you to have this done close by. The Warwick Evidence Systematic Review of the performance of NIPT found that the negative predictive value of NIPT was 99.9%. A midwife told me that there are two extra things the 12 week dating scan test for that’s not part of NIPT. Availability of Harmony varies by location. If your results are found to show low probability – an email will be sent to the email address confirmed with you at the time of your appointment. Cell-free foetal DNA (cff DNA) comes from the placenta. The Laboratory offers foetal sex testing and the sex chromosome aneuploidy panel testing as additional complimentary investigations. http://www.rapid.nhs.uk Once you have your results we always recommend that you present them to your usual healthcare professional whose contact details we take at the time of booking. However, large-scale studies show that the test has a 99% detection rate for Down’s Syndrome. The false positive rate for all trisomies is <0.1%. The Harmony blood test evaluates X and Y chromosome sequences, providing information on foetal sex and sex chromosome aneuploidy. Please bring your hand held notes with you to the scan. A Nuchal Translucency (NT) measurement (the thickness of the fluid at the back of the baby's neck) with ultrasound when combined with a blood test and other maternal information, provides an indication of the risk factor or likelihood of a baby being born with Down syndrome. You are welcome to bring +1 guest (no children currently allowed) to most of our clinics (Oxford is currently unable to accommodate +1 guest). I’ve done mine on Friday and the question now is whether I do the NHS one as well. Foetal sexing is also now available for twin pregnancies, but patients who are pregnant with more than one foetus are NOT eligible for the Harmony Prenatal Test with X and Y analysis. In the event of your results showing a high probability – you will be called on the telephone number confirmed with you at the time of your appointment by a member of our specialist team from Head Office. What does that mean? A high probability test result will apply to at least one fetus: The relative proportion of cell-free fetal DNA is reduced in women with a high BMI as they have more of their own cell-free DNA circulating in their blood. This may increase the chance of getting an inconclusive result. Non-invasive prenatal testing (NIPT) is a blood test taken from the mother that uses cutting-edge DNA technology to evaluate with remarkable accuracy whether a pregnancy has a high chance of certain chromosomal conditions – including Trisomy 21 – Down’s Syndrome, Trisomy 18 – Edward’s Syndrome and Trisomy 13 – Patau’s Syndrome. Please continue to have all your normal scans as usual and interpret all readings in context of your risk factors and family risks. There is the option of three different Non Invasive Prenatal Tests (NIPT) at The Birth Company; Harmony Test, Panorama Test and Safe Test, costing from £500 each. International Moms ususally weren’t covered by insurance. All our sonographers take care to follow the latest safety guidelines and are registered with the HCPC. A Non-Invasive Pregnancy Test (NIPT) is a simple blood test, taken from the mother, from as early as 10 weeks into pregnancy. Sex chromosome analysis – The sex chromosomes (X & Y) determine if we are male or female. The NIPT test can be performed on twin pregnancies but not additional (ie triplets or higher) and only when both foetuses are ongoing. Please be aware – we are a third party using TDL Genetics to analyse your blood test. Non-invasive prenatal testing (NIPT) uses cell-free DNA (cfDNA) derived from the pregnancy to evaluate possible chromosomal conditions in a pregnancy. The NIPT is analysed in the UK by our authorised partners: Harmony via TDL. Need to expose lower abdomen so ideally wear separate garments i.e trousers or skirt and top. For these reasons we do not recommend cell-free DNA testing in the case of demised twin. They can have a singleton or twin pregnancy resulting from natural conception or IVF using your own egg or a donor egg. However, currently due to a lack of research into the reliability of this test Ultrasound Direct are not offering this as an additional option at this present time. We have made maximum effort to make the Harmony Test + Scan affordable. Please contact the clinics listed here to know more about the NIPT they offer during pregnancy. The population-based PPV in the table was determined in a large prospective study of a first trimester routine-screening population. Previous techniques for prenatal genetic testing involved taking a sample of fetal cells, either from the placenta (a process known as chorionic villus sampling or CVS) or from cells shed by the fetus into the amniotic fluid (amniocentesis). In this event a new sample will need to be taken again at no extra cost. In booking a NIPT appointment with us you are agreeing to your personal information being shared with the relevant partners solely for the purpose of this test. 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