The symptoms for adults are same as they are for children, but there are some subtle differences, says Lenard A. Adler, MD, director of the adult ADHD program at … Most of the time, depression improves substantially with the first antidepressant tried. However, because it an antidepressant, it takes 2 to 4 weeks for TCAs like Tofranil to reach maximum efficacy. Wellbutrin is an antidepressant, which is sometimes also useful for treating ADHD (though not officially, which is why this is an “off-label” use). In your case, maybe the Ritalin is treating your ADHD by stimulating your brain, and the Wellbutrin is treating your depression and helping the Ritalin. Most antidepressants work well alongside ADHD stimulant meds, as well as with the nonstimulant Strattera (atomoxetine), though minor adjustments may need to be made. According to Dr. Donald Haupt, co-author of The Complete Idiot's Guide to Adult ADHD, he does prescribe these two types of medications together … I've had depression since I was 12, and anxiety. Tofranil can be effective for adults with ADHD and also in treating symptoms of depression and anxiety that often accompany ADHD. Anxiety is defined as an unpleasant feeling of nervousness or fear that is often accompanied by unrealistic thinking, dread, and panic. If the depressive symptoms persist, an antidepressant is usually added to the ADHD medication. Several types of antidepressant drugs can be used to treat ADHD. When stimulants are not effective, tricyclic antidepressants (TCAs) like Tofranil are sometimes prescribed. Given the choice, I treat ADHD first with a stimulant. This is based on my experience that a high percentage of patients (about 50 percent) report that their mood lifts when they have achieved optimal doses of stimulant-class medication. For some individuals, anxiety is an uncontrollable part of life - no matter what they do, they cannot escape the anxious thoughts, constant worry, and physical symptoms such as a fast heart rate. Certain antidepressants work by acting on brain chemicals called neurotransmitters—in particular norepinephrine and serotonin—causing them to linger in the spaces between nerve cells where they carry out their job of regulating mood. If left untreated, anxiety can become so extreme that a … Why Antidepressants Cause Fatigue . Attention deficit hyperactivity disorder (ADHD) is a common behavioral disorder diagnosed in roughly 10 percent of school-aged children and adolescents. Antidepressants, however, are generally not as effective as stimulants or Strattera at improving attention span and concentration. I've been on 6 different antidepressants and developed social anxiety disorder. 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