The COVID-19 pandemic has already caused over 1 million deaths. (required), Sample number if more than 1 sample was sequenced from the same epidemiological week and location (where required), Special designation for sequences derived from measles inclusion-body encephalitis (MIBE), subacute sclerosing panencephalitis (SSPE) cases or vaccine reactions (VAC) (optional). *All vaccine strains (e.g. Subtypes are designed with numerals—A1, D2 etc. Email: prota@cdc.gov, Dr. Bettina Bankamp The virus is enveloped by a lipid membrane and glycoproteins H and F are virion surface proteins that are associated with this lipid membrane. Additionally, the F protein can cause infected cells to directly fuse with neighboring uninfected cells forming syncytia. CDC twenty four seven. Atlanta, Georgia, 30329 The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. Jennifer L. Gardy, Monika Naus, Ashraf Amlani, Walter Chung, Hochan Kim, Malcolm Tan, Alberto Severini, Mel Krajden, David Puddicombe, Vanita Sahni, Althea S. Hayden, Reka Gustafson, Bonnie Henry, Patrick Tang, Whole-Genome Sequencing of Measles Virus Genotypes H1 and D8 During Outbreaks of Infection Following the 2010 Olympic Winter Games Reveals Viral Transmission Routes, … N, P and … In search of such a concept, we have analyzed a measles virus-based vaccine candidate targeting SARS-CoV-2. The virus causes measles, a highly contagious disease transmitted by respiratory aerosols that triggers a temporary but severe immunosuppression. The virus is spread by coughing and sneezing via close personal contact or direct contact with secretions. Encodes for eight proteins. [15] The WHO currently recognises 8 clades of measles (A–H). The genotyping scheme was introduced in 1998 and extended in 2002 and 2003. 2001;75:4399-4401). Viral Vaccine-Preventable Diseases Branch Measles virus has a single, non-segmented, negative-sense RNA genome with a linear arrangement of genes that are separated by an intergenic trinucleotide, GAA. Measles virus has a single, non-segmented, negative-sense RNA genome with a . [23][24], CS1 maint: multiple names: authors list (, nectin-4 (also called Poliovirus-Receptor-Like 4 (PVRL4)), "The Morbillivirus Receptor SLAM (CD150)", "Analysis of receptor (CD46, CD150) usage by measles virus", "The Host Cell Receptors for Measles Virus and Their Interaction with the Viral Hemagglutinin (H) Protein", "Host–Pathogen Interactions in Measles Virus Replication and Anti-Viral Immunity", "Origin of measles virus: divergence from rinderpest virus between the 11th and 12th centuries", "Purifying Selection Can Obscure the Ancient Age of Viral Lineages", "The evolutionary and epidemiological dynamics of the paramyxoviridae", "Complete Genome Sequences of Six Measles Virus Strains", "No endemic transmission of measles in the Americas since 2002", "Measles Virus Infection of Alveolar Macrophages and Dendritic Cells Precedes Spread to Lymphatic Organs in Transgenic Mice Expressing Human Signaling Lymphocytic Activation Molecule (SLAM, CD150)", "Measles virus blind to its epithelial cell receptor remains virulent in rhesus monkeys but cannot cross the airway epithelium and is not shed", "Macrophages and Dendritic Cells Are the Predominant Cells Infected in Measles in Humans", "In Vitro Measles Virus Infection of Human Lymphocyte Subsets Demonstrates High Susceptibility and Permissiveness of both Naive and Memory B Cells", "Measles Virus Transmission from Dendritic Cells to T Cells: Formation of Synapse-Like Interfaces Concentrating Viral and Cellular Components", "Measles Virus Infection of Epithelial Cells in the Macaque Upper Respiratory Tract Is Mediated by Subepithelial Immune Cells", "Cell-to-Cell Contact and Nectin-4 Govern Spread of Measles Virus from Primary Human Myeloid Cells to Primary Human Airway Epithelial Cells", Extranodal NK/T-cell lymphoma, nasal type, Progressive multifocal leukoencephalopathy, https://en.wikipedia.org/w/index.php?title=Measles_morbillivirus&oldid=999822622, Taxonbars using multiple manual Wikidata items, Taxonbars with from2 matching article title, Creative Commons Attribution-ShareAlike License, This page was last edited on 12 January 2021, at 03:45. Wild-type measles viruses have been divided into distinct genetic groups according to the nucleotide sequences of their hemagglutinin and nucleoprotein genes. Mailstop C-22 The MeVA assay allows the identification of vaccine reactions in about two hours. Measles morbillivirus (MeV), formerly called measles virus (MV), is a single-stranded, negative-sense, enveloped, non-segmented RNA virus of the genus Morbillivirus within the family Paramyxoviridae. [17], In the early stages of infection, the measles virus via CD150 (SLAMF1) receptor infects immune cells located in the host respiratory tract such as macrophages and dendritic cells. Measles virus (MeV) is a highly contagious, re-emerging, major human pathogen. Ono N, Tatsuo H, Hidaka Y, Aoki T, Minagawa H, Yanagi Y et al. This provides a significant safety advantage for laboratorians and greatly facilitates international shipments of virus isolates. 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